Cardiovascular and bone health

Regulation of phosphaturic hormones by dietary potassium

Research area to investigate

The activity of the renin-angiotensin-aldosterone system is altered by dietary intakes of sodium (Na) or potassium (K), which ultimately influences renal Na and K reabsorption or secretion, volume homeostasis and blood pressure (BP). In addition, there is emerging evidence that alterations in dietary Na and K intake affect phosphate (Pi) and calcium (Ca) balance, which influences cardiovascular and bone health. Increased dietary Na leads to adverse cardiovascular and bone mineral density (BMD) outcomes, whereas an increase in dietary K improves BMD. The molecular mechanisms for how increased dietary K intake has positive effects on bone and cardiovascular health remains unknown. In this project the overarching goal is to determine if various endocrine factors mediate crosstalk between dietary K intake, the renin-angiotensin-aldosterone system, and bone-cardiovascular health. The project will require working with genetically modified mice models, development of primary cultures of bone, imaging using micro-CT and potentially "omic"-based approaches.

Our new MSCA Postdoctoral Fellow should have these skills

Our new MSCA Postdoctoral Fellow should have proven skills in one or more of the following:

  • Development of primary cultures
  • Cell culture
  • Single-cell sequencing
  • Bioinformatics

Host group expertise

  • Proteomics and bioinformatics
  • Cell culture and ex vivo tissue culturing
  • High-resolution imaging
  • Animal models of disease
  • Gene modified mice

Host department

Are you interested?

Send your resume and a short description of your motivation for this project to the host supervisor before 31 March 2023.

The application process

Provisional timeline

  • 31 March 2023: Deadline for international postdocs’ enquiries concerning the published project description.
  • Mid-April 2023: The supervisor selects an applicant. 
  • 2 May 2023: Online workshop with writing consultants - supervisor and applicant start to write an application together.
  • June-July 2023: Online meeting between writing consultants, the supervisor and the applicant.
  • Mid-September 2023: EU deadline for applications to the MSCA programme. 
  • February 2024: The European Commission announces the recipients of the MSCA grants, with start in summer 2024.