Target discovery and mode of action of bioactive metabolites

We aim to understand how metabolism can be rewired to protect kidneys from disease.

We are interested in an unmet clinical, physiological and chemical problem: How and why kidneys fail, and what this means for the body. This is a problem with great social, economic and personal challenges and requires new ways of thinking and analysis. To approach this, we use a wide array of metabolic, mass spectrometric and bioinformatics tools, and integrate and benchmark big data sets with physiological function. Our results have unraveled new approaches and omics-guided targets for kidney disease in mice and men, in particular in the area of glomerular kidney disease.

A potential MSCA postdoc opportunity is available to evaluate novel targets that have emerged from resources generated in the lab. Using high-throughput analysis of metabolome, proteome and interaction data, we aim to characterize mode of action of new metabolites in the kidney. The aim of the study is to merge clinical, physiological, spatial and chemical information to determine which protective metabolites matter most for kidney and cardiovascular health. We hope that this will lead to the development of new metabolic interventions in kidney disease.

• Interest in deciphering complex biomedical problems
• Interest in inter-organ and intra-organ communication
• Interest in learning complex omics data analysis
• Bring some “special skill” to the group – a method, a tool, an organism
• Independent, motivated and teamplayer (think out of the box)

• Expertise in the area of kidney disease, omics, functional data, screening
• Mass spectrometry and integrative omics analysis
• Standard biochemical and cell culture laboratories, core facilities
• Wide collaborative opportunities

More about the research group