Target discovery and mode of action of bioactive metabolites
We aim to understand how metabolism can be rewired to protect kidneys from disease.
We are interested in an unmet clinical, physiological and chemical problem: How and why kidneys fail, and what this means for the body. This is a problem with great social, economic and personal challenges and requires new ways of thinking and analysis. To approach this, we use a wide array of metabolic, mass spectrometric and bioinformatics tools, and integrate and benchmark big data sets with physiological function. Our results have unraveled new approaches and omics-guided targets for kidney disease in mice and men, in particular in the area of glomerular kidney disease.
A potential MSCA postdoc opportunity is available to evaluate novel targets that have emerged from resources generated in the lab. Using high-throughput analysis of metabolome, proteome and interaction data, we aim to characterize mode of action of new metabolites in the kidney. The aim of the study is to merge clinical, physiological, spatial and chemical information to determine which protective metabolites matter most for kidney and cardiovascular health. We hope that this will lead to the development of new metabolic interventions in kidney disease.
Send your resume and a short description of your motivation for this project to the host supervisor before 31 March 2023.