Day 1

8:30-9:00 Coffee and registration

9:00-9:15 Opening of meeting Anne-Mette Hvas, Dean at the Faculty of Health, Aarhus University, Denmark

Welcome remarks Anders Børglum, Managing Professor of the Personalised Medicine Network, Aarhus University, Denmark

SESSION I: “HUMAN DIVERSITY” (Chair: Anders Børglum)

9:15-10:05 Opening Keynote: Study of human diversity Kári Stefánsson, deCode Genetics, Iceland

10:05-10:35 Genetics of ADHD – risk loci and genetic overlap with other phenotypes Ditte Demontis, Aarhus University, Denmark

10:35-10:50 Systematic investigation of allelic regulatory activity of psychiatric disorder risk variants Hyejung Won, University of North Carolina at Chapel Hill, NC, USA

10:50-11:10 Coffee with light refreshment, poster viewing and networking

SESSION II: “TOWARDS PERSONALISED PSYCHIATRY” (Chairs: Doug Speed & Ole Köhler-Forsberg)

11:10-12:00 Keynote: The potential and the barriers for genetic personalised medicine in psychiatry Cathryn Lewis, Kings College London, United Kingdom

12:00-12:30 Polygenic aspects of childhood neurodevelopmental disorders Jakob Grove, Aarhus University, Denmark

12:30-12:40 Flash talk: Polygenic liabilities and treatment trajectories in early-onset depression (presenter: Jessica Mundy)

12:40-13:35 Lunch and networking

13:35-15:05 Poster session and coffee & cake

SESSION III: “DISEASE PROGRESSION AND PHENOTYPIC VARIATION” (Chairs: Claus Gravholt & Camilla Blunk Brandt)

15:05-15:35 Deep learning approaches for analysis of population-wide disease progression data Søren Brunak, University of Copenhagen, Denmark

15:35-16.05 Expanding the phenotypic spectrum of calmodulinopathies Mette Nyegaard, Aalborg University, Denmark

16:05-16:35 Introducing a decision support tool - The Ischemic Heart Disease Algorithm - in clinical practice - a randomised clinical trial Henning Bundgaard, Rigshospitalet, Copenhagen, Denmark

16:35-16:55 Flash talks: Exploring the impact of BMI on cancer development (presenter: Johanne Ahrenfeldt) The information system, a unique work tool to optimize drug safety during pregnancy (presenter: Line Kolding og Jakob N. Henriksen)

17:30-20:00 Conference dinner/reception

Day 2

8:30-9:00 Coffee

SESSION IV: “ADVANCED STATISTICAL METHODS” (Chairs: Liselotte Vogdrup Petersen & Bjarni J. Vilhjálmson)

9:00-9:30 Mendelian Randomisation with Directed Acyclic Graphs learning: Opportunities and pitfalls in personalised medicine Leonardo Bottolo, University of Cambridge, United Kingdom

9:30-10:00 Machine learning with clinical purpose Adam Hulman, Aarhus University, Denmark

10:00-10:20 Flash talks: LDAK-PBAT: A Novel Pathway-Based Analysis Tool for Decoding the Genetics of Complex Diseases (presenter: Takiy Berrandou) Unraveling the regulation mechanism of the human flippase ATP8B1 (presenter: Poul Nissen)

10:20-10:50 Coffee with light refreshment, poster viewing and networking

SESSION V: “EPIDEMIOLOGICAL STUDIES” (Chairs: Uffe Birk Jensen & Hannah Chatwin)

10:50-11:40 Keynote: Using genetic epidemiology to inform personalised medicine Per Magnus, Norwegian Institute of Public Health, Norway

11:40-12:10 Early life exposures and pubertal development: results from the DNBC Puberty cohort Cecilia Ramlau-Hansen, Aarhus University, Denmark

12:10-13:10 Lunch and networking SESSION VI: “ADVANCED TECHNOLOGIES IN CANCER RESEARCH” (Chairs: Martin Bøgsted & Lars Dyrskjøt Andersen)

13:10-14:00 Keynote: Data-driven and functional precision medicine for acute myeloid leukemia and beyond Olli Kallioniemi, SciLifeLab and Karolinska Institute, Sweden

14:00-14:30 The power of circulating tumor cells in Immuno-Oncology Catherine Panabieres, University Medical Centre of Montpellier, France

14:30-15:00 T cell receptor landscape associate with metastasis in bladder cancer Nicolai Birkbak, Aarhus University, Denmark 15:00-15:30 Networking and coffee & cake SESSION VII: “APPLIED PERSONALISED MEDICINE” (Chairs: Deirdre Cronin Fenton & Mikkel Heide Schierup)

15:30-15:50 Flash talks: Social characteristics and adherence to adjuvant endocrine therapy in breast cancer patients (presenter: Julie Schmidt) Genetic variants of the serotonin transporter with functional and pharmacological impact (presenter: Steffen Sinning)

15:50-16:20 Treatment decisions for metastatic cancer patient – implementation of personalised medicine Britt Elmedal Laursen, Aarhus University, Denmark

16:20-16:45 Closing remarks, poster & flash talk awards