Globally, 3 out of 5 persons lose their lives to chronic inflammatory conditions, such as diabetes, cardiovascular disorders, cancer, chronic respiratory diseases, skin diseases, renal diseases and obesity. Inflammatory diseases are the most prevailing cause of death worldwide and the numbers keep rising.

The network focuses on reducing the burden of infectious and inflammatory diseases caused by pathogens, damaged cells, toxic compounds or radiation in order to develop new diagnostic and treatment technologies.

As a society, we need more knowledge about the correlation between e.g. inflammation and development of cancer, about biomarkers and about molecular mechanisms of autoimmunity in e.g. rheumatological conditions - not to mention chronic mucosal inflammation. In the inflammation network we collaborate interdisciplinearily in order to find answers.

We comprise a wide range of researchers with interest in diagnostic methods, epidemiological data, inflammatory markers and intracellular pathways, understanding of cell population and tissue structures, among others.

Focus groups

Paper of the Month

Vivi Schlünssen

The paper of the month is a systematic review (SR) and meta-analysis compiling data from both observational and intervention studies on the association between chronic low-grade inflammation and working conditions. The paper reflects an increasing interest within the environmental and occupational field for inflammatory markers possible preceding chronic disease with potentially important windows of opportunity for prevention of chronic disease.

The most interesting part of the SR is the work place intervention studies (16, including 8 RCT), where physical interventions (e.g. aerobic training, cycling to work) or mental interventions (e.g. stress resilience training, Yoga training) were investigated. The most commonly used markers for low grade inflammation was high sensitivity CRP, TNf-α and  IL-6

Workplace physical exercise interventions were associated with a decrease in C-reactive protein (P<0.001). For other workplace interventions, i.e. .mental and organizational/structural, results were inconclusive.

The authors conclude that the research base is still limited, but the SR support that exercise interventions at or relate to the workplace might be able to reduce chronic low-grade inflammation.

Kaltenegger et al: Associations of working conditions and chronic low-grade inflammation among employees: a systematic review and meta-analysis - PubMed (