Globally, 3 out of 5 persons lose their lives to chronic inflammatory conditions, such as diabetes, cardiovascular disorders, cancer, chronic respiratory diseases, skin diseases, renal diseases and obesity. Inflammatory diseases are the most prevailing cause of death worldwide and the numbers keep rising.
The network focuses on reducing the burden of infectious and inflammatory diseases caused by pathogens, damaged cells, toxic compounds or radiation in order to develop new diagnostic and treatment technologies.
As a society, we need more knowledge about the correlation between e.g. inflammation and development of cancer, about biomarkers and about molecular mechanisms of autoimmunity in e.g. rheumatological conditions - not to mention chronic mucosal inflammation. In the inflammation network we collaborate interdisciplinearily in order to find answers.
We comprise a wide range of researchers with interest in diagnostic methods, epidemiological data, inflammatory markers and intracellular pathways, understanding of cell population and tissue structures, among others.
Christian Lodberg Hvas
Fecal microbiota transplantation (FMT) is highly effective against recurrent Clostridioides difficile infection and a promising treatment for other microbiome-related disorders, but a comprehensive understanding of microbial engraftment dynamics is lacking.
In this Paper of the Month, Ianiro et al. performed an integrated shotgun metagenomic systematic meta-analysis of new and publicly available stool microbiomes collected from 226 triads of donors, pre-FMT recipients and post-FMT recipients across eight different disease types.
By exploring the dynamics of microbiome engraftment after FMT and their association with clinical variables, the study uncovered species-specific engraftment patterns and presented machine learning models able to predict donors that might optimize post-FMT specific microbiome characteristics for disease-targeted FMT protocols.
Ianiro et al. 2022: Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases Nature Medicine 28, 1913-1923
For more information about FMT in Denmark and Europe, please see the Centre for Faecel Microbioata Transplantation website
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